1146 LITHIUM: PLACENTAL TRANSFER, BREAST MILK EXCRETION, AND SERUM ELECTROLYTE CHANGES

Vigabatrin: placental transfer in vivo and excretion into breast milk of the enantiomers.

AIMS Vigabatrin is a new antiepileptic medication consisting of a racemic mixture of 50% active S enantiomer and 50% inactive R enantiomer. Since patients suffering from epilepsy may become pregnant, it is important to understand the extent of placental transfer of such medication. METHODS During steady-state, vigabatrin enantiomer concentrations were measured in maternal and umbilical blood ...

Terbutaline excretion into breast milk.

Oral treatment with the 12 adrenoceptor stimulating agent terbutaline produces bronchodilatation and relieves clinical symptoms in bronchial asthma (Legge et al., 1971; Formgren, 1975). Since bronchodilating therapy might be necessary during the lactation period, there is an obvious need for data on the excretion of terbutaline into breast milk and the plasma levels reached in nursing infants. ...

Excretion of Acebutolol and its Major Metabolite Diacetolol into Infant Blood Circulation and the Breast Milk

Acebutolol (AC) is a chiral b-adrenergic blocking drug, which is useful clinically as the racemate in treating hypertension and is metabolized to an equipotent chiral metabolite, diacetolol (DC). In this paper we report a case of a 32 year old woman who was receiving AC during her pregnancy and lactating time for management of hypertension. The maternal plasma level and breast milk as well as c...

Excretion of Acebutolol and its Major Metabolite Diacetolol into Infant Blood Circulation and the Breast Milk

Acebutolol (AC) is a chiral b-adrenergic blocking drug, which is useful clinically as the racemate in treating hypertension and is metabolized to an equipotent chiral metabolite, diacetolol (DC). In this paper we report a case of a 32 year old woman who was receiving AC during her pregnancy and lactating time for management of hypertension. The maternal plasma level and breast milk as well as c...

Excretion of centchroman in breast milk.